Table 2 Standardized incidence ratios (SIRs) of second primary malignancies (SPMs) by latency period after the diagnosis of chronic lymphocytic leukemia (CLL), patient age, and race over time

From: Trends in the risk of second primary malignancies among survivors of chronic lymphocytic leukemia

 

1973–1982 O/E (95% CI)

1983–1992 O/E (95% CI)

1993–2002 O/E (95% CI)

2003–2015 O/E (95% CI)

Latency period

 2–5 months

1.61a (1.2–2.11)

1.19 (0.9–1.54)

1.54a (1.23–1.89)

1.79a (1.52–2.08)

 6–11 months

1.26 (0.96–1.64)

1.04 (0.8–1.31)

1.02 (0.81–1.26)

1.44a (1.24–1.67)

 12–59 months

1.30a (1.18–1.44)

1.17a (1.08–1.28)

1.14a (1.06–1.24)

1.30a (1.22–1.39)

 60–119 months

1.11 (0.99–1.25)

1.07 (0.97–1.17)

1.22a (1.13–1.32)

1.34a (1.22–1.46)

 ≥120 months

1.08 (0.97–1.2)

1.05 (0.96–1.15)

1.18a (1.08–1.29)

1.41a (1.07–1.82)

Patient age

 15–49 years

1.53a (1.17–1.97)

1.31a (1.02–1.67)

1.52a (1.21–1.87)

2.14a (1.6–1.79)

 50–79 years

1.18a (1.10–1.26)

1.10a (1.04–1.16)

1.19a (1.13–1.25)

1.37a (1.3–1.44)

 ≥80 years

1.12 (0.93–1.34)

1.02 (0.87–1.19)

1.04 (0.9–1.2)

1.26a (1.13–1.4)

Patient race

 White

1.19a (1.12–1.26)

1.08a (1.03–1.14)

1.17a (1.12–1.23)

1.36a (1.3–1.43)

 Black

1.27 (0.97–1.65)

1.47a (1.18–1.81)

1.49a (1.21–1.8)

1.46a (1.21–1.75)

 Others

1.02 (0.33–2.38)

1.62a (1.01–2.45)

1.41 (0.99–1.95)

2.07a (1.55–2.72)

  1. O/E observed/expected, CI confidence interval
  2. aStatistically significant