Fig. 4: OTSSP167 treatment reduces tumor growth in vivo and prolongs overall survival. | Blood Cancer Journal

Fig. 4: OTSSP167 treatment reduces tumor growth in vivo and prolongs overall survival.

From: Maternal embryonic leucine zipper kinase is a novel target for diffuse large B cell lymphoma and mantle cell lymphoma

Fig. 4

a Balb/c mice were inoculated with murine A20 lymphoma cells and when tumor was palpable the mice were treated with OTSSP167 (10 mg/kg). Mice were sacrificed when tumor volume reached 1500 mm³. b Evaluation of the tumor volume of vehicle (n = 11, red) and OTSSP167-treated mice (n = 11, green). *p < 0.05, **p < 0.01, and ***p < 0.001. c Survival curve of vehicle (red) and OTSSP167-treated mice (green). d Expression of MELK and Aurora B kinase (AurB) was determined in samples from vehicle and OTSSP167-treated mice. β-actin was used as loading control. Quantification was performed with Image J.

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