Fig. 4: MYC and MYCN non-synonymous mutations comparison.
From: Molecular switch from MYC to MYCN expression in MYC protein negative Burkitt lymphoma cases
Mutations (red lollipops) annotated on protein primary sequence with additional information regarding post-translational modifications (PTMs) and domain composition. Linear motif annotations have been obtained from ELM (http://elm.eu.org/cgimodel.py?fun=smartResult&userId=QiKSrcdQR9&EXPECT_CUTOFF=100&r=1&bg=on). MYC mutations have been mapped to the canonical (isoform 1 from Swissprot, ID: P01106) protein isoform. Only mutations for MYCN positive cases are displayed. b Network representation of predicted effects at 3D interaction interfaces through Mechismo (http://mechismo.russelllab.org/). Predicted disabling, enabling and mixed effects are in indicated by red, green and orange arrows. c 3D cartoon representation (PDB ID: 1NKP) of mutations perturbing interaction interfaces. Sphere coloring is the same as for arrows in B. For MYC, we show mutation numberings referred to both the canonical amino acid sequence as well as to the isoform 2.
