Fig. 5: Regulatory loop between MYC and MYCN exists also in Namalwa and lymphoblastoid cell lines. | Blood Cancer Journal

Fig. 5: Regulatory loop between MYC and MYCN exists also in Namalwa and lymphoblastoid cell lines.

From: Molecular switch from MYC to MYCN expression in MYC protein negative Burkitt lymphoma cases

Fig. 5

a Silencing of MYC mRNA expression by siRNA nucleofection in Namalwa and lymphoblastoid (B) cell lines resulted in a lower expression of MYC mRNA along with higher expression of MYCN. MYC mRNA has been investigated by RT-qPCR applying designed and Taqman primers. b Transfected cells collected after MYC silencing showed MYCN protein expression by immunohistochemistry.

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