Table 1 Clinical data and representative mutation sites located on MYC and MYCN genes.
From: Molecular switch from MYC to MYCN expression in MYC protein negative Burkitt lymphoma cases
Case | Age | Sex | Epidemiology | Biopsy site | EBER | MYC FISH | Â | Â | PROTEIN | SNVs position | AA switch | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
MYC B.A. | MYC-IGH | MYC-IGK/IGL | MYC | MYCN | ||||||||
BL 8 | 14 | F | endemic | lymph node | − | + | + | n.p. | − | + | g.chr2:16086085G>A | V421I |
BL 82 | 7 | M | endemic | ileum | − | + | − |  + (IGL)/-(IGK) | − | + | g.chr2:16086115C>T g.chr8:128753056C>T | H431Y P406L |
BL 83 | 8 | M | endemic | soft tissue | + | + | + | n.p. | − | − | g.chr8:128750542T>G g.chr8:128750610G>T g.chr8:128750607G>A | Y27D Q49H Q48Q |
Bl 84 | 9 | F | endemic | maxilla | + | + | + | n.p. | − | + | g.chr2:16086046G>A g.chr8:128752981G>A | V408M R381K |
BL 85 | 11 | M | endemic | oral cavity | + | + | + | n.p. | − | + | g.chr2:16086104C>T | T427I |
BL 86 | 4 | F | endemic | lymph node | + | + | + | n.p. | − | + | g.chr2:16086208C>T g.chr8:128753079G>A | R462W A414T |
BL 87 | 10 | M | endemic | maxilla | + | + | − |  + (IGL) / -(IGK) | − | + | g.chr2:16086076G>A g.chr8:128753064G>A | A418T V409I |
BL 91 | 45 | M | sporadic | stomach | − | + | + | n.p. | − | − | g.chr8:128750540A>G g.chr8:128750543A>C | N26S Y27S |
BL 92 | 79 | F | sporadic | vagina | − | + | + | n.p. | − | − | g.chr8:128750543A>G | Y27C |
