Table 3 Multivariable analysis results^a.

	Number	Relative risk	95% CI lower limit	95% CI upper limit	p-value	Overall p-value
Non-relapse mortality
2000–2005	76	1.00				0.40
2006–2010	238	0.80	0.51	1.24	0.32
2011–2015	413	0.74	0.48	1.15	0.18
Progression/relapse
2000–2005	76	1.00				0.48
2006–2010	238	0.77	0.51	1.17	0.22
2011–2015	413	0.82	0.54	1.24	0.34
Progression-free survival
2000–2005	76	1.00				0.54
2006–2010	238	0.84	0.60	1.15	0.27
2011–2015	413	0.85	0.61	1.18	0.32
Overall survival
2000–2005	76	1.00				0.055
2006–2010	238	0.753	0.545	1.04	0.09
2011–2015	413	0.667	0.479	0.929	0.02

CI confidence interval.
^aDetailed results of multivariate analysis are provided in Supplementary Table S2

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