Table 3 Treatment response by cytogenetic group.

From: Cytogenetic abnormalities in multiple myeloma: association with disease characteristics and treatment response

First line therapy

ORR (≥PR) n (%)

≥VGPR rate n (%)

HR trans

SR trans

P value

IgH trans (any)

Trisomies

P value

HR trans

SR trans

P value

IgH trans (any)

Trisomies

P value

Overall

214 (88)

428 (80)

0.006

642 (83)

557 (83)

1.00

122 (50)

202 (38)

0.001

324 (42)

246 (36)

0.046

PI

83 (87)

156 (81)

0.19

239 (83)

134 (71)

0.002

48 (51)

80 (41)

0.17

128 (44)

69 (37)

0.09

IMiD

52 (81)

136 (73)

0.19

188 (75)

261 (87)

<0.001

15 (23)

49 (26)

0.74

64 (26)

92 (31)

0.22

PI + IMiD

73 (96)

124 (93)

0.38

197 (94)

148 (96)

0.48

57 (75)

69 (51)

0.001

126 (60)

81 (53)

0.17

Other

6 (75)

12 (57)

0.67

18 (62)

14 (45)

0.21

2 (25)

4 (19)

1.00

6 (21)

4 (13)

0.50

  1. IgH immunoglobulin heavy chain, IMiD immunomodulatory drug, PI proteasome inhibitor, PR partial response, trans translocation.
  2. Bold values indicate statistical significance P values < 0.05.
Back to article page