Table 2 Risk stratification of smoldering multiple myeloma (SMM).

From: Multiple myeloma current treatment algorithms

High-risk SMM

Any 2–3 of the following high-risk factors:

 Serum monoclonal protein >2 gm/dL

 Serum free light-chain ratio (involved/uninvolved) >20

 Bone marrow plasma cells >20%

Intermediate-risk SMM

Any 1 high-risk factor

Low-risk SMM

No high-risk factor

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