Table 4 Multivariable Cox proportional hazard ratios for all-cause mortality with stepwise adjustments for patient characteristics.

From: Race/ethnicity in systemic AL amyloidosis: perspectives on disease and outcome disparities

 

Median OS (years)

Unadjusted

Model 1

Model 2

Model 3

Model 4

 

HR (95% CI)

P value

HR (95% CI)

P value

HR (95% CI)

P value

HR (95% CI)

P value

HR (95% CI)

P value

NHW

3.4

Ref.

 

Ref.

 

Ref.

 

Ref.

 

Ref.

 

NHB

2.5

1.15 (0.95–1.37)

0.145

1.24 (1.03–1.49)

0.020

1.19 (0.93–1.50)

0.161

0.92 (0.63–1.35)

0.673

0.82 (0.50–1.34)

0.427

Hispanic

4

0.92 (0.70–1.22)

0.573

0.97 (0.73–1.29)

0.846

1.05 (0.72–1.52)

0.811

0.93 (0.57–1.52)

0.082

0.60 (0.29–1.23)

0.162

NHO

7.9

0.61 (0.39–0.95)

0.029

0.72 (0.46–1.13)

0.151

0.61 (0.36–1.04)

0.069

0.61 (0.29–1.32)

0.210

0.70 (0.32–1.52)

0.367

Overall P among groups

  

0.059

 

0.050

 

0.133

 

0.631

 

0.377

  1. Model 1 adjusted for demographic variables only (age, sex). Model 2 added sociodemographic and lifestyle variables (education, marital status, smoking, alcohol consumption, BMI). Model 3 added physiologic variables (BU cardiac stage, dFLC >180 mg/mL). Model 4 added stem cell transplantation treatment. The overall P value derived by Type III test estimated the effect of race/ethnicity in each model.
  2. OS overall survival, HR hazard ratio, CI confidence interval, ref. reference group.
  3. Bold values signify statistical significance.