Fig. 7: RASSF2 expression is broadly predictive of Rac GTPase signal transduction in AML. | Blood Cancer Journal

Fig. 7: RASSF2 expression is broadly predictive of Rac GTPase signal transduction in AML.

From: The RUNX1-ETO target gene RASSF2 suppresses t(8;21) AML development and regulates Rac GTPase signaling

Fig. 7

a Normalized RASSF2 expression (counts) in t(8;21) AML patient cohort (left) and full TCGA AML cohort (right) showing stratification of patients into two sub-cohorts for purpose of differential gene expression analysis: t(8;21) and RASSF2-high (defined as upper quartile by gene expression). b Bar graph showing top-nine significantly enriched Gene Ontology (GO) terms, with negative enrichment (downregulation) in t(8;21) cohort, as determined by differential gene expression analysis of t(8;21) AML patient cohort vs. RASSF2-high AML patient cohort as defined in a.

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