Table 3 Univariate and multivariate analysis of clinical and biological factors influencing PFS and OS of transplant-ineligible patients in our cohort.

From: Molecular profiling of immunoglobulin heavy-chain gene rearrangements unveils new potential prognostic markers for multiple myeloma patients

Variable

Univariate analysis for PFS

Multivariate analysis for PFS

Univariate analysis for OS

Multivariate analysis for OS

 

Median survival

p

HR [95% CI]

p

Median survival

p

HR [95% CI]

p

ECOG score

        

 0−1

26.94

0.003

 

NS

 

NS

  

 2−4

21.35

       

Serum hemoglobin

        

 <9 g/dL

14.03

0.001

 

NS

24.54

0.002

 

NS

 ≥9 g/dL

28.32

   

64.85

   

Post induction response

        

 sCR/CR

49.35

0.008

0.311 [0.196−0.494]

1E−05

Not reached

0.00026

0.347 [0.154−0.780]

0.010

 VGPR/PR

23.88

   

53.19

   

Cytogenetic risk

        

 High risk

36.30

0.196

 

NS

78.59

0.031

0.369 [0.164−0.832]

0.016

 Standard risk

25.03

   

39.95

   

IGHD4 usage

        

 Yes

14.49

0.036

 

NS

 

NS

  

 No

27.96

       

IGHD4-11 usage

        

 Yes

14.16

0.0003

 

NS

 

NS

  

 No

26.94

       

IGHD2 and IGHD3 usage

        

 Yes

34.46

0.012

0.552 [0.361−0.845]

0.006

 

NS

  

 No

23.46

       

SHM level

        

 <7%

23.46

0.006

 

NS

34.73

0.00024

0.291 [0.137−0.618]

0.001

 ≥7%

26.45

   

64.85

   
  1. Univariate analysis was first performed to evaluate the role of each clinical and biological variable described in this study. The table only shows statistically significant variables that were later included in the multivariate analysis. Median survival is shown in months.
  2. HR hazard ratio, CI confidence interval, NS nonsignificant.
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