Table 5 Predictors* of arterial, venous and total thrombosis in univariate analysis.

From: Validation of the IPSET score for thrombosis in patients with prefibrotic myelofibrosis

 

Arterial thrombosis (n = 30)

Venous thrombosis (n = 28)

Variables

HR (95% CI)

P value

HR (95% CI)

P value

Male sex

  

0.49 (0.22–1.09)

0.079

Age, years

1.04 (1.01–1.07)

0.004

  

 ≥60 years

2.01 (0.96–4.21)

0.062

 ≥65 years

2.88 (1.37–6.05)

0.005

Previous thrombosis

  

3.06 (1.41–6.64)

0.005

 Arterial

    

 Venous

  

5.53 (2.32–12.2)

<0.0001

Leukocyte count ≥10×109/L

2.43 (1.11–5.31)

0.026

  

CV risk factorsa (at least 1)

2.16 (1.01–4.62)

0.047

  

Driver mutations

    

 JAK2V617F

3.35 (1.15–9.74)

0.027

  

Nondriver mutations

    

 EZH2

10.1 (1.03–99)

0.047

  

 HMR

13.1 (1.34–127)

0.027

  
  1. *Variables with a P < 0.10 in univariate analysis.
  2. aHistory of smoking, hypertension, diabetes mellitus, hypercholesterolemia.
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