Table 1 Baseline characteristics and organ involvement.
Mayo cohort N = 473 N (%) or Median (IQR) | Pavia cohort, N = 575 N (%) or Median (IQR) | |
|---|---|---|
Median age, years | 63 (56–69) | 64 (56–70) |
Sex, males | 309 (65) | 335 (58) |
Involved light chain, lambda | 354/467 (78) | 450/575 (78) |
Median M-protein (g/dL) | 0 (0–0.6) | 0.8 (0–1.5) |
Median dFLC (mg/dL) | 19 (8–55) | 19 (9–52) |
dFLC <5 mg/dL | 63 (13) | 39 (7) |
Bone marrow plasma cells (%) | 10 (5–12) | 11 (7–20) |
NT-Pro BNP (pg/mL) | 1625 (327–4296) | 2215 (704–5578) |
Troponin-T (ng/mL) | 0.02 (0.01–0.05) | Not available |
Troponin-I (ng/mL) | Not available | 0.05 (0.02–0.13) |
Median 24 h urine protein (mg) | 2629 (375–7008) | 2561 (392–6590) |
Median GFR (ml/min/1.73 m2 BSA) | 65 (48–82) | 69 (49–87) |
Median alkaline phosphatase (U/L) | 86 (69–118) | 149 (88–217) |
Mayo 2012 stage 1/2/3/4 | 125/123/115/93 (27/27/25/20) (N = 456) | 109/159/151/111 (20/30/28/22) (N = 530) |
Mayo 2004 stage 1/2/3a/3b | 107/205/108/37 (23/45/24/8) (N = 457) | 78/276/107/69 (15/52/20/13) (N = 530) |
Renal stage 1/2/3 (%) | 229/183/53 (49/39/11), N = 465 | 285/213/68 (50/37/13) N = 566 |
iFISH—t (11; 14) | 172/325 (53) | Not available |
iFISH—trisomy/tetrasomy | 67/326 (21) | Not available |
Organ involvement | ||
Heart | 332 (70) | 454 (79) |
Kidney | 330 (70) | 399 (69) |
Liver | 66 (14) | 64 (11) |
Gastrointestinal system | 101 (21) | 13 (2) |
Autonomic nervous system | 47 (10) | 61 (10) |
Major organ involveda | ||
One major organ involved | 255 (54) | 269 (47) |
Two major organs involved | 181 (37) | 268 (46) |
Three major organs involved | 37 (8) | 38 (7) |
More than one major organ involved | 218 (46) | 306 (53) |
