Fig. 3: Summary of most relevant genes somatically mutated in CLPD-NK: functions and putative drivers. | Blood Cancer Journal

Fig. 3: Summary of most relevant genes somatically mutated in CLPD-NK: functions and putative drivers.

From: A high definition picture of somatic mutations in chronic lymphoproliferative disorder of natural killer cells

Fig. 3

a KEGG and Reactome pathway-derived network of somatic mutations detected in CLPD-NK, by WES (circles) and by STAT3 targeted screening (triangle); direct, indirect and predicted relations between genes and gene products annotated in pathways topologies are shown; node colors indicate different groups of pathways and functions, according to the table in panel (b); circular node size is proportional to the evaluation of possible driver role considering mutation VAF and predicted impact and gene function and expression; b Genes involved in different groups of pathways mutated in each patient highlight functions recurrently hit in different patients (gene name in bold, VAF ≥ 0.1; bold and underlined VAF ≥ 0.2).

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