Table 1 Clinical and molecular features of the 13 CLPD-NK patients analyzed by WES.

From: A high definition picture of somatic mutations in chronic lymphoproliferative disorder of natural killer cells

CLPD-NK Pat.

Sex

Age

WBC

ANC

Hb

PLT

ALC

Immunophenotype

KIR expression restricted

NKG2

76

M

45

6.4

2.5

147

300

4.96*

CD16+ CD56+ CD57+

158B

C

100

M

52

10

2.36

151

227

9.12*

CD16+ CD56+ CD57+

158E

A

115

M

79

7

2.2

144

163

3.76*

CD16+ CD56+ CD57+

158B

Negative

117

M

49

7.1

2.67

155

245

5.24*

CD16+ CD56+ CD57+

158B

A

165

M

43

3.16*

1.32*

153

60*

1.90

CD16+ CD56+ CD57−

Not expressed

A

187

M

73

5.16

1.94

159

198

8.89*

CD16+ CD56− CD57+

Not expressed

A

260

M

59

12.35*

1.31*

133

238

9.95*

CD16+ CD56+ CD57+

Not expressed

A

337

M

67

5.6

2.53

147

217

4.42*

CD16+ CD56+ CD57+

158A

A

448

M

59

5

3.98

88*

317

4.15*

CD16+ CD56+ CD57+

Not expressed

A

452

M

44

6.4

2.29

145

207

5.31*

CD16+ CD56− CD57+

158B

A

1253

F

65

4.1

0.01*

120*

157

3.35

CD16+ CD56− CD57+

NA

NA

1272

F

47

7.7

NA

NA

NA

NA

CD16+CD56− CD57+

NA

NA

1260

F

46

10.9

1.49*

114*

281

10.89*

CD16+ CD56− CD57+

NA

NA

  1. All patients resulted wild type for STAT3 and STAT5B (see Methods). *indicates values outside the normal range (WBC 3.5–11 × 109/L; ANC 1.9–5.3 × 109/L; Hb 125–169 g/L; PLT 110–330 × 109/L; ALC 1.18–3.62 × 103/μL). All patients presented restricted KIR expression (either presence of only one KIR or total absence of KIR expression) and most frequently a heterodimer of the A type NKG2 with CD94+. WBC white blood count, ANC absolute neutrophil count, ALC absolute lymphocyte count, Hb hemoglobin, PLT platelets, M male, F female, NA not available.
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