Fig. 3: Differential DNA methylation analysis between T-ALL and T-LBL. | Blood Cancer Journal

Fig. 3: Differential DNA methylation analysis between T-ALL and T-LBL.

From: DNA methylation and copy number variation profiling of T-cell lymphoblastic leukemia and lymphoma

Fig. 3

a Venn diagram showing the common, overlapping 634 DM-CpGs between T-ALL and T-LBL. b Heat map of avg.β values of the 634 DM-CpGs in T-ALL, T-LBL and non-malignant reference samples. The hierarchical cluster analysis of the DM-CpGs generated four clusters of CpG sites which are marked on the right. c Heat map showing 128 DM-CpGs from cluster 2 and 4 (from Fig. 3b), that represent methylomic differences between T-ALL and T-LBL, independent of CIMP profiles. d PCA of the 128 DM-CpGs showing the separation of T-ALL and T-LBL samples, based on tissue type, age group and CIMP status.

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