Fig. 8: Volcano plots of the differential drug sensitivity between UHC groups.
From: “Direct to Drug” screening as a precision medicine tool in multiple myeloma
Volcano plots identify drugs with differential sensitivity between patient subpopulations (mean AUC difference between two classes). The upper panel identifies drugs, which are more sensitive in resistant group B than C (left) and inversely more sensitive in group C than B (right); the bottom panel provides the same analysis for groups D versus E. Drug annotation is provided in Supplemental Table 1. Group B has significantly higher sensitivity to HDAC inhibitors, while group C has higher sensitivity than B to agents inhibiting PI3K/mTOR, cell cycle, and the proteasome. Group D is more sensitive than E to dexamethasone, HDAC inhibitors, PI3K/mTOR inhibitors, and to agents targeting MAPK and EGFR, while group E is more sensitive than D to melphalan.
