Table 2 Multivariate analysis for factors affecting survival outcomes.
Model #1 (n = 132) | n | Relapse | Non-relapse mortality | Disease-free survival | Overall survival | ||||
|---|---|---|---|---|---|---|---|---|---|
HR (95% CI) | p- Value | HR (95% CI) | p-Value | HR (95% CI) | p-Value | HR (95% CI) | p-Value | ||
NGS-MRD at pre-HSCTa | |||||||||
Negative | 75 | 1 | 1 | 1 | |||||
Positive | 57 | 5.59 (2.07–15.12) | 0.001 | 2.26 (1.37–4.77) | 0.003 | 2.07 (1.08–3.95) | 0.027 | ||
Disease state | |||||||||
CR1 | 128 | 1 | 1 | 1 | |||||
CR2 | 4 | 2.57 (0.59–11.16) | 0.207 | 2.60 (0.79–8.60) | 0.116 | 3.48 (1.02–11.49) | 0.046 | ||
Cohort | |||||||||
Cohort #1 | 63 | 1 | |||||||
Cohort #2 | 69 | 0.42 (0.14–1.25) | 0.119 | ||||||
Relationship | |||||||||
Related | 80 | 1 | |||||||
Unrelated | 52 | 2.47 (0.92–6.58) | 0.072 | ||||||
Sex match | |||||||||
Female to male | 21 | 1 | |||||||
Others | 111 | 0.33 (0.12–0.85) | 0.022 | ||||||
Model #2 (n = 114) | n | Relapse | Non-relapse mortality | Disease-free survival | Overall survival | ||||
|---|---|---|---|---|---|---|---|---|---|
HR (95% CI) | p-Value | HR (95% CI) | p-Value | HR (95% CI) | p-Value | HR (95% CI) | p-Value | ||
NGS-MRD at post-HSCT-1ma | |||||||||
Negative | 91 | 1 | 1 | 1 | |||||
Positive | 23 | 4.06 (1.64–10.05) | 0.002 | 2.85 (1.39–5.83) | 0.004 | 2.48 (1.14–5.42) | 0.022 | ||
Disease state | |||||||||
CR1 | 110 | 1 | 1 | 1 | |||||
CR2 | 4 | 1.98 (0.42–9.27) | 0.384 | 2.27 (0.64–8.05) | 0.204 | 3.22 (0.88–11.85) | 0.078 | ||
Cohort | |||||||||
Cohort #1 | 54 | 1 | |||||||
Cohort #2 | 60 | 0.73 (0.22–2.41) | 0.610 | ||||||
Relationship | |||||||||
Related | 68 | 1 | |||||||
Unrelated | 46 | 3.06 (0.94–10.02) | 0.064 | ||||||
Sex match | |||||||||
Female to male | 20 | 1 | |||||||
Others | 94 | 0.26 (0.09–0.74) | 0.012 | ||||||
