Table 1 Patient and leukemia characteristics.

Age at initial diagnosis

0.83

Median (Range)

16 (4–35)

16 (3–40)

16 (3–40)

Interquartile range

11, 23

10, 23

11, 23

Age at first relapse

0.005

Median (Range)

23 (9–42)

35 (22–51)

25 (9–51)

Interquartile range

17, 29

26, 41

19, 35

Sex

1.00

Female

7 (29.2%)

4 (33.3%)

11 (30.6%)

Male

17 (70.8%)

8 (66.7%)

25 (69.4%)

Race

0.54

Asian

1 (4.2%)

0 (0%)

1 (2.8%)

Hispanic

11 (45.8%)

9 (75%)

20 (55.6%)

Unknown

1 (4.2%)

0 (0%)

1 (2.8%)

White

10 (41.7%)

3 (25%)

13 (36.1%)

Black

1 (4.2%)

0 (0%)

1 (2.8%)

Phenotype at diagnosis

1.00

B cell

21 (87.5%)

11 (91.7%)

32 (88.9%)

T cell

3 (12.5%)

1 (8.3%)

4 (11.1%)

Times from first diagnosis to 1st relapse (years)

Median (Range)

6 (5–9)

20 (10–28)

7 (5–28)

Interquartile range

5, 7

13, 23

6, 13

CNS

0.47

NO

19 (79.2%)

9 (75%)

28 (77.8%)

YES (diagnosis + relapse)

0 (0%)

1 (8.3%)

1 (2.8%)

YES (relapse)

5 (20.8%)

2 (16.7%)

7 (19.4%)

WBC count at diagnosis (1000/µL)

0.96

Median (Range)

5 (1–178)

6 (1–55)

5 (1–178)

Interquartile range

3, 26

3, 30

3, 30

WBC at first relapse

0.36

Median (Range)

7 (1–158)

30 (2–219)

9 (1–219)

Interquartile range

4, 17

7, 108

6, 102

Cytogenetics at diagnosis

0.62

KMT2A (MLL)

1 (4.3%)

1 (8.3%)

2 (5.6%)

Normal Karyotype

8 (34.8%)

2 (16.7%)

10 (27.8%)

Others

4 (17.4%)

1 (8.3%)

5 (13.9%)

Ph+

1 (4.3%)

1 (8.3%)

2 (5.6%)

Unknown/Missing

10 (41.7%)

7 (58.3%)

17 (47.2%)

Cytogenetics at 1st relapse

0.92

Complex

2 (8.3%)

1 (8.3%)

3 (8.3%)

KMT2A (MLL)

2 (8.3%)

1 (8.3%)

3 (8.3%)

NK

10 (41.7%)

4 (33.3%)

14 (38.9%)

Others

4 (16.7%)

1 (8.3%)

5 (13.9%)

Ph+

1 (4.2%)

2 (16.7%)

3 (8.3%)

Unknown/Missing

5 (20.8%)

3 (25%)

8 (22.2%)

Location of 1st relapse

BM

20 (83.3%)

8 (66.7%)

28 (77.8%)

0.21

Combined

3 (12.5%)

1 (8.3%)

4 (11.1%)

EMD

1 (4.2%)

3 (25%)

4 (11.1%)