Table 2 Survival intervals and rates by era of diagnosis.

Deaths, n (%)

1660 (71)

182 (98)

532 (93)

663 (77)

283 (40)

Median age at death, years (IQR)

66 (58–73)

63 (56–69)

66 (57–73)

66 (58–73)

68 (61–75)

Median OS, years (95% CI)

3.0 (2.8–3.4)

1.4 (1.0–1.8)

2.6 (2.2–3.0)

3.3 (2.9–3.8)

4.6 (3.8–5.6)

6-month mortality rate, % (95% CI)

16 (15–18)

23 (18–30)

17 (14–21)

17 (14–19)

13 (10–16)

2-year OS, % (95% CI)

60 (58–62)

41 (34–48)

56 (52–60)

60 (57–64)

71 (67–75)

10-year OS, % (95% CI)

20 (18–22)

7 (4–12)

18 (15–21)

22 (19–25)

–

Age ≥70 years

2.1 (1.8–2.4)

0.8 (0.5–1.6)

1.8 (1.0–2.0)

2.5 (1.8–3.3)

2.2 (1.6–2.6)

HDM/SCT-treated

7.6 (6.8–8.2)

–

5.5 (4.5–6.9)

8.0 (6.9–9.2)

8.8 (8.1–NR)

Non-SCT-treated

2.9 (2.6–3.3)

1.6 (0.8–2.3)

2.6 (2.0–3.5)

2.9 (2.3–3.3)

3.8 (2.9–4.8)

Presence of cardiac involvement

2.0 (1.6–2.3)

0.9 (0.6–1.3)

1.4 (0.9–2.0)

1.7 (1.4–2.3)

2.6 (2.4–3.5)

Absence of cardiac involvement

7.0 (6.1–7.9)

2.6 (1.9–3.2)

7.2 (5.8–8.3)

6.8 (5.9–8.2)

8.8 (7.5–10.1)