Table 3 Comparison of allogeneic HSCT prognostic scoring systems.
HCT-CI [6] | rDRI [9] | EBMT [10] | PAM [11] | AL-EBMT [12] | HCT-CR [31] | Iowa/Mayo | |
|---|---|---|---|---|---|---|---|
Years of transplantation | 1997–2003 | 2008–2010 | 1990–2005 | 1990–2002 | 2000–2011 | 2010–2016 | 2000–2016 |
Disease included | AML, ALL, CML, CLL, MDS, MM, NHL, HD, AA, Nonmalignant indications | MPN, HD, NHL, T-cell NHL, CLL, MCL, CML, AML, BL, ALL, MDS, MM | AML, ALL, CML, MDS, MM, NHL, AA | AML, ALL, CML, CLL, MDS, MM, NHL, HL, AA, nonmalignant | AML, ALL | AML, ALL, MDS, NHL, CLL, CML, HL, MPN and MM | ALL, AML, MDS MPN, NHL, Other |
Primary endpoint | NRM | OS | OS | OS | 100-day mortality | OS | OS |
Secondary endpoints | OS | None | NRM and relapse | None | DFS, GRFS, NRM and RI | DFS | |
AUC/C-statistic for OS in testing cohort | 0.66 | 0.63 | 0.62 | 0.69 | 0.70 | 0.69 | 0.62 |
Total sample size | 1055 | 13,131 | 56,505 | 2802 | 28,236 | 1447 | 651 |
Sample size training/testing | 708/347 | 9,849/2,382 | NA | 1,401/1,401 | 19,765/8,47 1 | NA | 273/378 |
Major variables included in the final tool | 13 system comorbidities | Disease, disease status at HSCT, karyotype (AML and MDS) | Disease stage, donor type (MRD or MUD), age of recipient, time from HSCT, sex match of recipient and donor | Age of recipient (<50, 50–60, >60), donor type (MRD or MUD), disease risk conditioning regimen, renal disease, hepatic disease, pulmonary disease | Disease stage, KPS, Age of recipient (<37, ≥37), Time from diagnosis to HSCT, Donor type (MSD or MUD), Year of HSCT (2003–2003, subsequent) Annual allo- HSCT center experience, donor and recipient CMV serostatus | HCT-CI/age, rDRI | KPS, HCT-CI, rDRI, donor age, CMV serostatus |
Model development methods used in original publication | Cox regression | Cox regression | Cox regression | Cox regression | Nonparametric data mining approach | Cox regression | Cox regression |
Training and validation cohort derivation in the original model | Randomly split internal cohort | Randomly split internal cohort | Randomly split internal cohort | Randomly split internal cohort | Randomly split internal cohort | Independent internal cohort | Independent external cohort |
Donor type included | MRD MUD | MRD MUD | MRD MUD | MRD MUD | MRD MUD | MRD MUD MMRD MMUD | MRD MUD MMRD MMUD |
