Fig. 3: NCOR2 links to NuRD complex and downregulate MYC via CD180 inhibition.
From: Low NCOR2 levels in multiple myeloma patients drive multidrug resistance via MYC upregulation
A Western blot analysis of co-immunoprecipitation of endogenous proteins by anti-NCOR2 in MM.1 s were analyzed. B Western blot analysis of H3K9ac and H3K27ac in MM.1 s and NCOR2 knock out MM.1 s were analyzed. C NCOR2 binding at the promoters of CD180. y-axis values represent read densities normalized to total number of reads. D mRNA expression level of CD180 in NCOR2 knock out cell line (KO) and control MM.1 s cell line (WT) were examined by qPCR. E mRNA expression level of MYC in NCOR2 knock out cell line (KO) and control MM.1 s cell line (WT) with or without LPS stimulation (10 nM, 4 h) were examined by qPCR. *P < 0.01.
