Table 2 Outcomes in newly diagnosed and relapsed/refractory patients with IDH2 mutant acute myeloid leukemia.

From: Efficacy and safety of enasidenib and azacitidine combination in patients with IDH2 mutated acute myeloid leukemia and not eligible for intensive chemotherapy

Response

Newly diagnosed n = 7

Relapsed/refractory n = 19

CRc

7 (100)

11 (58)

CR

5 (72)

5 (26)

CRi

2 (28)

6 (32)

MRD negativity by FCM

7/7 (100)

2/9 (22)

Not evaluable

0

1 (5)

No response

0

7 (37)

Median number of cycles given (range)

3 (1–8)

4 (1–17)

Median time to best response, months (range)

1.6 (1.0–4.2)

1.8 (0.8–5.4)

  1. CRc -composite complete remission rate = CR + CRi, CR- complete remission, CRi -CR with incomplete hematologic recovery, MRD- measurable residual disease, FCM- flowcytometry
  2. All results expressed as No. (%) or median [Minimum–maximum], unless specified.