Table 2 Genetic profile according to fusion transcripts status.
From: Clinico-biological features of T-cell acute lymphoblastic leukemia with fusion proteins
Fusion Group | Notch signaling | Cell cycle | Epigenetic factors | IL7R/JAK/STAT signaling | Transcription factors | PI3K/Akt signaling | Ras signaling | Total |
|---|---|---|---|---|---|---|---|---|
MLLT10 | 59% (n = 17) | 41% (n = 12) | 76% (n = 22) | 3% (n = 1) | 52% (n = 15) | 24% (n = 7) | 24% (n = 7) | 29 |
KMT2A/SET | 53% (n = 18) | 41% (n = 14) | 59% (n = 20) | 3% (n = 1) | 35% (n = 12) | 21% (n = 7) | 32% (n = 11) | 34 |
ABL1 | 75% (n = 15) | 80% (n = 16) | 60% (n = 12) | 5% (n = 1) | 45% (n = 9) | 5% (n = 1) | 50% (n = 10) | 20 |
ETS | 67% (n = 4) | 67% (n = 4) | 67% (n = 4) | 17% (n = 1) | 17% (n = 1) | 17% (n = 1) | 33% (n = 2) | 6 |
Negative | 79% (n = 143) | 76% (n = 136) | 57% (n = 102) | 1% (n = 1) | 37% (n = 67) | 19% (n = 35) | 20% (n = 36) | 180 |
