Fig. 6: Favorable T cell receptor beta (TRB) clusters with low generation probability (low pGen) are enriched in patients with T cell richness boost after azacitidine. | Blood Cancer Journal

Fig. 6: Favorable T cell receptor beta (TRB) clusters with low generation probability (low pGen) are enriched in patients with T cell richness boost after azacitidine.

From: Azacitidine-induced reconstitution of the bone marrow T cell repertoire is associated with superior survival in AML patients

Fig. 6

Comparing TRB clusters determined with the GLIPH2 algorithm, we identified clusters with low generation probability (−log generation probability >29,89) which were only shared between healthy donors (HD) and AML patients on day 15 after azacitidine (AZA) or enriched in post-AZA samples compared to pretreatment samples (day 0; A). These low generation probability clusters were enriched in AML patients with elevated T cell repertoire richness after AZA (B).

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