Table 3 Overall survival, univariate and multivariate analyses.
Baseline | n/N | Univariate for OS | Â | Multivariate 1 | Multivariate 2 | |||||
|---|---|---|---|---|---|---|---|---|---|---|
| Â | Â | Baseline | Â | Â | Â | Â | Â | Â | Â | Â |
| Â | Â | HR | 95%CI | p value | HR | 95%CI | p value | HR | 95%CI | p value |
Myeloma high-risk | 201/574 | 1.76 | 1.26, 2.46 | 0.001 | NI | NI | NI | 1.83 | 1.30, 2.56 | 0.0005 |
MRD positive | 155/268 | 1.13 | 0.68, 1.87 | 0.65 | – | – | – | – | – | – |
Mass-Fix positive | 437/575 | 1.64 | 1.05, 2.57 | 0.03 | 1.64 | 1.05, 2.57 | 0.03 | 1.74 | 1.11, 2.74 | 0.0151 |
<CR | 479/575 | 1.33 | 0.82, 2.19 | 0.26 | – | – | – | – | – | – |
SIFE pos | 387/574 | 1.07 | 0.74, 1.54 | 0.47 | – | – | – | – | – | – |
| Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | NS |
Pre-maintenance | ||||||||||
Myeloma high-risk (post-I) | See above | 1.76 | 1.26, 2.46 | 0.001 | NI | NI | NI | 1.76 | 1.26, 2.46 | 0.001 |
MRD positive | 59/273 | 0.87 | 0.45, 1.67 | 0.67 | – | – | – | NS | NS | NS |
Mass-fix positive | 329/480 | 1.33 | 0.87, 2.04 | 0.18 | – | – | – | NS | NS | NS |
<CR | 303/482 | 1.42 | 0.94, 2.14 | 0.09 | – | – | – | NS | NS | NS |
SIFE pos | 259/481 | 0.92 | 0.63, 1.35 | 0.68 | – | – | – | NS | NS | NS |
1-year | ||||||||||
Myeloma high-risk (post-I) | See above | 1.76 | 1.26, 2.46 | 0.001 | NI | NI | NI | 2.29 | 1.31, 4.02 | 0.004 |
MRD positive | 42/251 | 3.57 | 2.01, 6.33 | <0.0001 | 2.77 | 1.50, 5.12 | 0.0012 | 2.83 | 1.53, 5.24 | 0.0009 |
Mass-Fix positive | 221/423 | 1.88 | 1.44, 2.45 | <0.0001 | 1.93 | 1.04, 3.56 | 0.036 | 1.96 | 1.06, 3.61 | 0.03 |
<CR | 232/434 | 1.77 | 1.12, 2.78 | 0.014 | NS | NS | NS | NS | NS | NS |
SIFE pos | 203/432 | 1.52 | 1.18, 1.96 | 0.0014 | NS | NS | NS | NS | NS | NS |
