Table 1 Clinical features of LGLL patients with and without isolated anemia, and LGLL patients with isolated anemia presenting with and without PRCA.
From: Isolated anemia in patients with large granular lymphocytic leukemia (LGLL)
Clinical characteristics | Without isolated anemia (n = 210) | With isolated anemia (n = 34) | P (w/ vs. w/o isolated anemia) | Isolated anemia with PRCA (n = 13) | Isolated anemia without PRCA (n = 21) | P (isolated anemia w/ vs. w/o PRCA) |
|---|---|---|---|---|---|---|
Sex, n | ||||||
Male:female | 126:84 | 30:4 | 0.001 | 11:2 | 19:2 | 0.627 |
Age, median (range), y | 65 (39–91) | 70 (32–90) | 0.124 | 72 (41–90) | 70 (32–87) | 0.810 |
Medical history, n (%) | ||||||
Rheumatoid arthritis | 38 (19%) | 1 (3%) | 0.023 | 1 (8%) | 0 (0%) | 0.400 |
Hematologic malignancies | 32 (16%) | 10 (29%) | 0.054 | 4 (31%) | 6 (29%) | 0.290 |
Non-hematologic malignancies | 23 (11%) | 6 (18%) | 0.299 | 2 (15%) | 4 (19%) | 0.340 |
BM/PBSCT transplantation prior to LGLL diagnosis | 4 (2%) | 2 (6%) | 0.207 | 1 (8%) | 1 (5%) | 0.480 |
Solid organ transplantation prior to LGLL diagnosis | 6 (3%) | 3 (9%) | 0.123 | 2 (15%) | 1(5%) | 0.270 |
B symptoms, n (%) | 17 (8%) | 1 (3%) | 0.483 | 7 (54%) | 9 (43%) | 0.220 |
Splenomegaly, n (%) | 42 (21%) | 6 (18%) | 0.749 | 2 (15%) | 2 (10%) | 0.350 |
Lymphadenopathy, n (%) | 3 (1%) | 1 (3%) | 0.464 | 0 (0%) | 1 (5%) | 0.620 |
Red cell transfusion dependent, n (%) | 35 (17%) | 18 (53%) | <0.0001 | 13 (100%) | 5 (24%) | <0.0001 |
Hemoglobin (g/dL), median (range) | 11.4 (3.5–14.8) | 9.1 (5.0–12.7) | <0.0001 | 8.5 (5.0–9.7) | 9.3 (5.2–12.7) | 0.120 |
MCV (fl), median (range) | 94.5 (72–127) | 99.9 (83.5–128.8) | 0.017 | 94.6 (83.5–111) | 100.9 (84.1–128.8) | 0.035 |
Reticulocytes (%), median (range) | 1.78 (0.13–8.77) | 0.93 (0.07–6.09) | 0.009 | 0.48 (0.07–0.65) | 1.23 (0.61–6.09) | 0.002 |
Reticulocytes (×109/L), median (range) | 53.8 (2.5–186,620) | 19.3 (1.9–211.3) | 0.036 | 10.5 (1.9–19) | 30.5 (16.9–211.3) | 0.010 |
Erythropoietin (mIU/mL), median (range) | 90 (8.5–68,200) | 420 (14–2883) | 0.466 | 853 (260–2608) | 151.9 (14–2883) | 0.210 |
Absolute Neutrophil count (×109/L), median (range) | 0.9 (0.0–3.8) | 2.5 (1.6–11) | 0.013 | 2.6 (1.6–11) | 2.4 (1.6–5.4) | 0.745 |
Absolute lymphocyte count (×109/L), median (range) | 3.0 (0.7–14.3) | 4.0 (0.6–9.0) | 0.078 | 2.6 (0.6–9.0) | 4.4 (1.5–9.0) | 0.316 |
Absolute LGLL count (×109/L), median (range) | 2.0 (0.5–30) | 2.1 (0.5–9.8) | 0.668 | 1.8 (0.5–6.6) | 2.6 (0.5–9.8) | 0.127 |
Platelet (×109/L), median (range) | 183 (20–680) | 283 (113–755) | <0.0001 | 246 (113–610) | 293 (157–755) | 0.609 |
