Table 2 Details of treatment post ASCT.

From: Treatment and outcomes of patients with light chain amyloidosis who received a second line of therapy post autologous stem cell transplantation

Variable

Cohort (n = 292)

Treatment post ASCT, n (%)

 Alkylator + PI ± dex, or PI ± dex

118 (40)

  CyBorD

64 (54)

  Vd

51 (43)

  Id

2 (2)

  VMP

1 (1)

 Alkylator + 2nd-gen IMiD ± dex, or 2nd-gen IMiD ± dex

77 (26)

  Rd

59 (77)

  Pd

10 (13)

  CRd

8 (10)

 Alkylator + steroid, or steroids monotherapy

55 (19)

  Melphalan + steroids

39 (71)

  Cyclophosphamide + steroids

2 (4)

  dex

14 (25)

 2nd-gen IMiD + PI ± dex

17 (6)

  VRd

10 (59)

  IRd

5 (29)

  KPd

1 (6)

  KRd

1 (6)

 Alkylator + thalidomide ± dex

14 (5)

  Td

13 (93)

  CTd

1 (7)

 Daratumumab-based

11 (4)

  Dara ± dex

6 (55)

  DPd

3 (27)

  DRd

1 (9)

  DVd

1 (9)

  1. ASCT autologous stem cell transplantation, PI proteasome inhibitor, dex dexamethasone, CyBorD cyclophosphamide + bortezomib + dexamethasone, Vd bortezomib + dexamethasone, Id ixazomib + dexamethasone, VMP bortezomib + melphalan + dexamethasone, gen generation, IMiD immunomodulatory drug, Rd lenalidomide + dexamethasone, Pd pomalidomide + dexamethasone, CRd cyclophosphamide + lenalidomide + dexamethasone, VRd bortezomib + lenalidomide + dexamethasone, IRd ixazomib + lenalidomide + dexamethasone, KPd carfilzomib + pomalidomide + dexamethasone, KRd carfilzomib + lenalidomide + dexamethasone, Td thalidomide + dexamethasone, CTd cyclophosphamide + thalidomide + dexamethasone, Dara daratumumab, DPd daratumumab + pomalidomide + dexamethasone, DRd daratumumab + lenalidomide + dexamethasone, DVd daratumumab + bortezomib + dexamethasone.