Table 3 Univariate and multivariate analysis for OS.

From: Treatment and outcomes of patients with light chain amyloidosis who received a second line of therapy post autologous stem cell transplantation

Variable

Univariate analysis

Multivariate analysis

HR (95% CI)

P

HR (95% CI)

P

Age >65 at relapse

1.4 (0.99–1.97)

0.05

1.2 (0.78–1.9)

0.3

Mayo 2012 stage (III/IV) at diagnosis

2.4 (1.58–3.6)

<0.0001

1.6 (1.01–2.6)

0.04

BMPC ≥10% at diagnosis

1.3 (0.93–1.81)

0.1

1.14 (0.75–1.75)

0.5

Organs involved >2 at diagnosis

1.05 (0.70–1.56)

0.8

Conditioning melphalan 200 mg/m2 at diagnosis

0.43 (0.3–0.6)

<0.0001

0.45 (0.27–0.74)

0.001

Receiving induction therapy

1.23 (0.88–1.7)

0.2

  1. OS overall survival, HR hazard ratio, CI confidence interval, BMPC bone marrow plasma cell.
  2. The bold values indicate a statistically significant result.