Blood Cancer Journal

Table 4 Factors associated with risk of MGUS progression.

From: Body mass index associated with monoclonal gammopathy of undetermined significance (MGUS) progression in Olmsted County, Minnesota

			Univariate			Univariate^a					Multivariable^b
	N	Event	HR	95% CI	P	N	Event	HR	95% CI	P	HR^a	95% CI	P
BMI (≥25)
Overall	555	56	2.14	1.05–4.36	0.04	446	49	2.07	0.97–4.42	0.06	1.92	0.90–4.11	0.09
Male	282	33	1.39	0.57–3.36	0.47	223	27	1.21	0.46–3.21	0.70	1.13	0.42–2.99	0.81
Female	273	23	3.55	1.06–11.9	0.041	223	22	3.49	1.03–11.8	0.044	3.46	1.02–11.8	0.047
Isotype (non-IgG)
Overall	580	56	2.84	1.68–4.80	0.0001	446	49	3.22	1.83–5.65	<0.0001	3.17	1.79–5.60	<0.0001
Male	290	33	2.50	1.25–4.99	0.01	223	27	2.64	1.22–5.70	0.01	2.99	1.17–5.71	0.02
Female	290	23	3.44	1.52–7.82	0.003	223	22	4.11	1.77–9.58	0.001	3.79	1.58–9.07	0.003
M protein (≥1.5 g/dl)
Overall	556	55	2.57	1.50–4.42	0.001	446	49	2.50	1.41–4.45	0.002	2.22	1.23–3.99	0.008
Male	285	33	2.03	0.99–4.20	0.055	223	27	1.70	0.75–3.90	0.21	1.64	0.70–3.84	0.26
Female	271	22	3.64	1.57–8.41	0.003	223	22	3.84	1.66–8.86	0.002	3.20	1.36–7.55	0.008
FLC_r (Abnormal)
Overall	520	53	3.39	1.98–5.82	<0.0001	446	49	3.49	1.99–6.12	<0.0001	2.58	1.45–4.59	0.001
Male	262	30	2.32	1.13–4.77	0.023	223	27	2.47	1.16–5.29	0.02	1.96	0.89–4.32	0.10
Female	258	23	5.72	2.42–13.5	<0.0001	223	22	5.47	2.29–13.1	0.0001	3.97	1.64–9.59	0.002
C-statistic
Overall											0.75	0.68–0.82
Male											0.71	0.60–0.82
Female											0.81	0.72–0.90

^aAlso adjusted for age at MGUS screening date.
^bFor overall: model includes 446 MGUS cases (with 49 events) who had complete clinical data available; for male: model includes 223 MGUS cases (with 27 events) who had complete clinical data available; for female: model includes 223 MGUS cases (with 22 events) who had complete clinical data available.
Univariate and multivariable Cox regression models.

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