Table 3 Survival data and characteristics of the ESS70+ in the training and validation sets.
Training set (Complete cases; N = 556) | Validation set (Complete cases; N = 505) | |
|---|---|---|
Median FU (month) [IQR] | 58 [33–60] | 46 [19–60] |
Median OS (month) [IQR] | 11 [3–31] | 10 [3–26] |
KM 5-Year Survival probability [95%CI] | 0.123 [0.095–0.156] | 0.128 [0.094–0.166] |
S0 at 5 years (Cox OS with LP = 0) | 0.183 | 0.194 |
Mean LP (SD) | 0.32 (0.43) | 0.48 (0.49) |
Mean SCORE (SD) | 2 (3) | 3 (3) |
Risk categories | N (%) | N (%) |
Lower risk <2 | 283 (51) | 203 (40) |
Intermediate risk [2–5] | 226 (41) | 219 (43) |
Higher risk >5 | 47 (8) | 83 (16) |
Risk categories | Median OS (month) [IQR] | Median OS (month) [IQR] |
Lower risk <2 | 18 [4–43] | 16 [6–39] |
Intermediate risk [2–5] | 9 [2–24] | 9 [3–19] |
Higher risk >5 | 3 [1–7] | 5 [2–10] |
Risk categories | KM 5-Year Survival probability [95%CI] | KM 5-Year Survival probability [95%CI] |
Lower risk <2 | 0.15 [0.10–0.21] | 0.17 [0.11–0.24] |
Intermediate risk [2–5] | 0.09 [0.06–0.14] | 0.10 [0.06–0.17] |
Higher risk >5 | Not observed (0.02 [0.00–0.10] at 42 month) | 0.06 [0.02–0.15] |
Risk categories [Lower/Intermediate/Higher] | C-Index | C-Index |
0.59 [0.56–0.62] | 0.59 [0.57–0.62] | |
Risk categories [Lower/Intermediate /Higher] | R²D | R²D |
0.08 [0.04–0.13] | 0.07 [0.03–0.12] | |
Risk categories | Complete Remission, n (%) | Complete Remission, n (%) |
Lower risk <2 | 192 (67.8) | 144 (70.9) |
Intermediate risk [2–5] | 115 (50.9) | 105 (47.9) |
Higher risk >5 | 18 (38.3) | 25 (30.1) |
Risk categories | Day-30 death, n (%) | Day-30 death, n (%) |
Lower risk <2 | 27 (9.5) | 17 (8.4) |
Intermediate risk [2–5] | 40 (17.7) | 20 (9.1) |
Higher risk >5 | 16 (34.0) | 15 (18.1) |
Risk categories | Day-60 death, n (%) | Day-60 death, n (%) |
Lower risk <2 | 43 (15.2) | 24 (11.8) |
Intermediate risk [2–5] | 54 (23.9) | 46 (21.0) |
Higher risk >5 | 22 (46.8) | 25 (30.1) |
