Fig. 3: Stem cell properties are related to the SLA. | Blood Cancer Journal

Fig. 3: Stem cell properties are related to the SLA.

From: Phenotypically-defined stages of leukemia arrest predict main driver mutations subgroups, and outcome in acute myeloid leukemia

Fig. 3

A Percentage of leukemic stem cells (CD34+CD38−CD123+) among blasts according to SLA in the TUH cohort (Kruskal–Wallis test). B–D Patient-derived xenograft from 70 AML patient samples in 446 mice. A group of five mice is classically used to test an AML sample with an injected dose of 107 cells per mouse. Engraftment is assessed in a delay of 16 weeks. B Percentage of mice with >0.5% of human leukemic cells detected in bone marrow samples by flow cytometry. C Evaluation of human leukemic engraftment in bone marrow samples of each experiment. Each point represents the mean of all PDX of a donor. D Expansion fold is calculated as a ratio between engrafted cells in mice bone marrow and spleen and injected leukemic cells.

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