Table 1 Comparison of Significant Differences between L-CH and M-CH.
From: Lymphoid clonal hematopoiesis: implications for malignancy, immunity, and treatment
Lymphoid Clonal Hematopoiesis | Myeloid Clonal Hematopoiesis | |
|---|---|---|
Frequency of CHIP in Adults aged 40 to 70 | 1.3% [17] | 5.8% [17] |
Frequency of mCAs in Adults aged 40 to 70 | 0.8% [17]a | 0.4% [17]a |
Most Frequent CHIP Mutations and Distribution | DUSP22, FAT1, KMT2D, SYNE1, and ATM mutations account for ~20% of L-CHIP variants [17] | DNMT3A, TET2, and ASXL1 mutations account for 87% of M-CHIP variants [17] |
Most Frequent mCAs | Tri12, LOH_ITPKB, Del13q, LOH_MIR16-1, LOH_NOTCH1, Del10q [17]b | LOH_TCL1A, Del20q, LOH_EP300, LOH_JAK2, Del5q, Tri8 [17]b |
Stages of maturation where mutations may occur | HSCs, immature lymphoid precursors, and mature lymphocytes | HSCs and immature myeloid precursors |
