Fig. 2: Intracellular flow cytometry measurements of IL-17A, IL-17F and IFNγ in CD4 and CD8 T cells treated with idelalisib.
From: Circulating Th17 T cells at treatment onset predict autoimmune toxicity of PI3Kδ inhibitors
A Absolute number of CD4 T cells positive for the indicated cytokine at C1 (prior to treatment), C2 and C5, comparing patients with early toxicity (Tox) to either delayed or no toxicity (No Tox). The bottom panel is the ratio of IL17F:A. B Absolute number of CD8 T cells positive for the indicated cytokine at C1 (prior to treatment), C2 and C5, comparing patients with early toxicity (Tox) to either delayed or no toxicity (No Tox). The bottom panel is the ratio of IL17F:A. *p ≤ 0.05; **p ≤ 0.01; ***p ≤ 0.001; ****p ≤ 0.0001.
