Fig. 1: Distribution, co-mutational spectrum and survival analysis for AML with mutated STAG2. | Blood Cancer Journal

Fig. 1: Distribution, co-mutational spectrum and survival analysis for AML with mutated STAG2.

From: Alterations of cohesin complex genes in acute myeloid leukemia: differential co-mutations, clinical presentation and impact on outcome

Fig. 1

Graphic representation of the domain structure of STAG2 and positions of STAG2 mutations in 88 AML patients (A). Mutations of STAG2 are categorized by function (missense=blue, termination=red), clonal rank (dominant=red/subclonal=blue), number of mutations, and variant allele fraction, and associated co-mutations (B). For detailed information on co-mutations and results of individual significance tests, see Tab. S4. Survival analysis using the Kaplan-Meier method and log-rank test for event-free (C), relapse-free (D) and overall survival (E) differentiating between STAG2-mutated and STAG2-wildtype AML.

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