Fig. 4: Distribution, co-mutational spectrum and survival analysis for AML with mutated SMC3. | Blood Cancer Journal

Fig. 4: Distribution, co-mutational spectrum and survival analysis for AML with mutated SMC3.

From: Alterations of cohesin complex genes in acute myeloid leukemia: differential co-mutations, clinical presentation and impact on outcome

Fig. 4

Graphic representation of the domain structure of SMC3 and positions of SMC3 mutations in 20 AML patients (A). Mutations of SMC3 are categorized by function (missense=blue, termination=red), clonal rank (dominant=red/subclonal=blue), number of mutations, and variant allele fraction, and associated co-mutations (B). For detailed information on co-mutations and results of individual significance tests, see Tab. S14. Survival analysis using the Kaplan-Meier method and logrank test for event-free (C), relapse-free (D) and overall survival (E) differentiating between SMC3-mutated and SMC3-wildtype AML.

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