Fig. 5: Model: effects of SNPs and splice factor deregulation on HMMR splicing. | Blood Cancer Journal

Fig. 5: Model: effects of SNPs and splice factor deregulation on HMMR splicing.

From: Identification of disease-related aberrantly spliced transcripts in myeloma and strategies to target these alterations by RNA-based therapeutics

Fig. 5

A demonstrates the effects of SNPs, while B shows the effects of PTBP1/2 overexpression on HMMR splicing. These alterations compromise complex A formation and downstream lead to alterations in the first etherification reaction. In the figure, “A” and “(Y)n” represent splicing branch point (BP) and polypyrimidine tract (PPT) of splicing, respectively.

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