Table 2 Multivariate logistic regression variables for predicting a worsening frail status at 1 year following diagnosis.

From: Dynamic frailty risk assessment among older adults with multiple myeloma: A population-based cohort study

Demographics

aORa

95% CI

P-value

MM diagnosis year (per yr)

1.01

0.97–1.04

0.78

Age (per year)

1.01

1.00–1.03

0.04

Sex

Female

0.82

0.71–0.96

0.01

Race

White

REF

REF

REF

Black

1.15

0.91–1.45

0.26

Other

0.64

0.46–0.89

0.01

Medicaid Enrollment

1.24

1.02–1.51

0.03

Frailty status at diagnosis*

Nonfrail

REF

REF

REF

Pre-frail

0.50

0.35–0.72

<0.01

Mildly-frail

0.25

0.17–0.35

<0.01

Moderately frail

0.19

0.13–0.27

<0.01

MM therapy at diagnosis

PI

REF

REF

REF

IMID

0.75

0.63–0.90

<0.01

Combination (PI + IMID)

1.56

1.28–1.90

<0.01

  1. aaOR, odds ratio adjusted for other listed variables.
  2. *Patients with severely frail status at baseline or who died within 1 year of diagnosis were excluded as frailty status could not further worsen or were not assessable for worsening frailty.
  3. IMID Immunomodulatory Drug, PI proteosome inhibitor, OS overall survival, dx diagnosis.
Back to article page