Table 2 Effects of nonsynonymous BCL2 mutation on FL outcomes.
From: Relationship between BCL2 mutations and follicular lymphoma outcome in the chemoimmunotherapy era
VAF ≥20%a | EFS | OS | Transformation | Lymphoma death | Non-lymphoma death | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Treatment | N | Adjustment | EFS | 95% CI | p value | HR | 95% CI | p value | HR | 95% CI | p value | HR | 95% CI | p value | HR | 95% CI | p value |
All | 199 | None | 1.29 | 0.88–1.91 | 0.19 | 1.82 | 1.05–3.17 | 0.034 | 1.15 | 0.51–2.60 | 0.73 | 1.41 | 0.67–2.95 | 0.37 | 2.31 | 0.89–6.02 | 0.087 |
All | 199 | FLIPI, Treatment | 1.55 | 1.02–2.35 | 0.043 | 1.74 | 0.87–3.11 | 0.063 | |||||||||
Non-systemic | 97 | None | 1.91 | 0.99–3.67 | 0.052 | 2.14 | 0.87–5.29 | 0.10 | 3.01 | 1.04–8.78 | 0.043 | 1.38 | 0.29–6.53 | 0.69 | 2.44 | 0.65–9.13 | 0.18 |
Non-systemic | 97 | FLIPI | 1.70 | 0.88–3.30 | 0.12 | 1.93 | 0.77–4.87 | 0.16 | |||||||||
R-based | 91 | None | 1.33 | 0.75–2.36 | 0.33 | 1.99 | 0.82–4.78 | 0.12 | 0.64 | 0.13–3.11 | 0.58 | 1.16 | 0.39–3.45 | 0.8 | N/A (3 deaths) | ||
R-based | 91 | FLIPI | 1.29 | 0.72–2.29 | 0.73 | 1.96 | 0.81–4.72 | 0.13 | |||||||||
VAF ≥5%b | EFS | OS | Transformation | Lymphoma death | Non-lymphoma death | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Treatment | N | Adjustment | HR | 95% CI | p value | HR | 95% CI | p value | HR | 95% CI | p value | HR | 95% CI | p value | HR | 95% CI | p value |
All | 199 | None | 1.15 | 0.80–1.65 | 0.44 | 1.63 | 0.96–2.78 | 0.073 | 1.03 | 0.48–2.19 | 0.94 | 1.07 | 0.52–2.20 | 0.85 | 2.54 | 0.99–6.53 | 0.053 |
All | 199 | FLIPI, Treatment | 1.22 | 0.84–1.77 | 0.31 | 1.43 | 0.82–2.47 | 0.21 | |||||||||
Non-systemic | 97 | None | 1.26 | 0.74–2.12 | 0.40 | 1.82 | 0.84–3.95 | 0.13 | 1.56 | 0.58–4.18 | 0.38 | 1.01 | 0.37–3.78 | 0.99 | 2.31 | 0.74–7.25 | 0.15 |
Non-systemic | 97 | FLIPI | 1.16 | 0.69–1.97 | 0.57 | 1.67 | 0.76–3.70 | 0.20 | |||||||||
R-based | 91 | None | 1.19 | 0.68–2.10 | 0.54 | 1.58 | 0.66–3.82 | 0.30 | 0.9 | 0.22–3.69 | 0.88 | 0.9 | 0.30–2.69 | 0.85 | N/A (3 deaths) | ||
R-based | 91 | FLIPI | 1.11 | 0.63–1.98 | 0.72 | 1.23 | 0.51–2.99 | 0.64 | |||||||||
