Table 2 Adjusted effect of post-remission treatment on cost according to younger and older AML population.

From: Cost comparison of post-remission strategies in younger and older AML patients in France

 

AML patients ≥18 and ≤60 years old

AML patients >60 years old

Variables

Exp(β) [95 CI]

p

Exp(β) [95 CI]

p

Age

1 [1–1.01]

0.427

1.01 [0.98–1.03]

0.628

Sex

Women

1

 

1

 

Men

1.01 [0.91–1.13]

0.802

0.95 [0.74–1.23]

0.722

Allo-HSCT

0

1

 

1

 

1

3.28 [2.86–3.77]

<0.001

2.00 [1.18–3.38]

0.010

Favorable

1

 

1

 

Cytogenetic risk

Intermediate

1.02 [0.85–1.23]

0.826

1.11 [0.82–1.49]

0.584

Adverse

1.06 [0.98–1.16]

0.162

0.70 [0.46–1.06]

0.090

Relapse or death during study period

0

1

 

1

 

1

0.99 [0.79–1.24]

0.932

1.23 [0.59–2.57]

0.584

Treatment for younger AML

HDAC-135

1

   

HDAC-123

0.84 [0.75–0.94]

0.002

  

Numbers of cycles

1.57 [1.45–1.7]

<0.001

  

Treatment for older AML

IDAC

  

1

 

SDAC/a

  

0.24 [0.18–0.31]

<0.001

  1. Generalized estimating equation model with Gamma distribution and log link; AML acute myeloid leukemia, HDAC-123 high-dose cytarabine on Days 1–3, HDAC-135 high-dose cytarabine on Days 1, 3, and 5, SDAC standard doses of cytarabine associated with a dose of anthracycline, IDAC intermediate doses of cytarabine, CI confidence interval.