Table 1 Baseline characteristics of the cohort.

From: Real-world results of autologous stem cell transplantation in newly diagnosed multiple myeloma: a report from the Canadian Myeloma Research Group database

Characteristic

Single ASCT (n = 3507)

Tandem ASCT (n = 314)

Total (n = 3821)

Male sex, n (%)

2054 (58.6%)

192 (61.1%)

2246 (58.8%)

Age at treatment initiation, median (range)

61 (26-77)

60 (26-72)

61 (26-77)

Myeloma isotype, n (%)

IgG

2067 (63.2%)

188 (61.6%)

2255 (63.1%)

IgA

677 (20.7%)

80 (26.2%)

757 (21.2%)

Light chain only

474 (14.5%)

29 (9.5%)

503 (14.1%)

Others

53 (1.6%)

8 (2.7%)

61 (1.6%)

Unknown or missing, n

236

9

245

ISS Staging

Stage I

1105 (36.4%)

79 (29.9%)

1184 (35.9%)

Stage II

1074 (35.4%)

83 (31.4%)

1157 (35.0%)

Stage III

859 (28.2%)

102 (38.7%)

961 (29.1%)

Unknown or missing, n

469

50

519

R-ISS Staging

Stage I

630 (29.6%)

44 (20.2%)

674 (28.7%)

Stage II

1290 (60.6%)

132 (60.6%)

1422 (60.6%)

Stage III

208 (9.8%)

42 (19.4%)

250 (10.7%)

Unknown or missing, n

1379

96

1475

Hemoglobin, g/L, median (range)

107.0 (27.0-173.0)

100.5 (39.0-164.0)

106.0 (27.0-173.0)

Platelet count, 109/L, median (range)

223.0 (2.8-977.0)

199.0 (5.0-6.7.0)

220 (2.8-977.0)

Beta 2-microglobulin, nmol/L, median (range)

288.0 (20.9-9164.0)

352.4 (85.6-3698.0)

291.7 (20.9-9164.0)

Albumin, g/L, median (range)

37.0 (8.0-54.0)

37.0 (14.0-53.0)

37.0 (8.0-54.0)

Calcium, mmol/L, median (range)

2.39 (1.23-6.37)

2.4 (1.22-4.6)

2.38 (1.23-6.37)

Creatinine > 177 umol/L, n (%)

522 (16.2%)

60 (20.7%)

582 (16.6%)

Unknown or missing, n

294

24

318

Elevated LDH, > 250 U/L, n (%)

587 (25.2%)

92 (36.7%)

679 (26.3%)

Unknown or missing, n

1175

63

1238

FISH cytogenetics, n (%)

t(4;14)

240 (11.0%)

87 (39.4%)

327 (13.6%)

Unknown or missing, n

1331

93

1424

17p

238 (10.6%)

91 (40.8%)

329 (13.3%)

Unknown or missing, n

1261

91

1352

t(14;16)

63 (4.1%)

29 (21.8%)

92 (5.5%)

Unknown or missing, n

1971

181

2152

Cytogenetic risk classification, n (%)

High-risk*

503 (29.9%)

201 (84.5%)

704 (36.7%)

Standard-risk

1178 (70.1%)

37 (15.5%)

1215 (63.3%)

Unknown or missing, n

1826

76

1902

  1. *High-risk: presence by FISH of any one or combination of del17p, t(4;14) and t(14;16).
Back to article page