Table 5 Treatment and outcomes in 3821 newly diagnosed ASCT patients.
Treatments | mPFS | p-value | mOS | p-value |
|---|---|---|---|---|
No. of induction regimens | ||||
1 regimen (n = 3445) | 36.2 (34.1–38.1) | 0.001 | 126 (120–138) | 0.011 |
2 regimens (n = 376) | 27.9 (24.3–33.9) | 118 (93.7 NRY) | ||
No. of ASCTs | ||||
Single (n = 3507) | 35.4 (33.6–37.3) | 0.62 | 126 (120–138) | 0.23 |
Tandem (n = 314) | 34.2 (30.2–47.5) | 113 (84.4-NRY) | ||
Single ASCT and maintenance given | ||||
Standard-risk (n = 769) | 54.7 (47.9–60.3) | 0.002 | 164.2 (158.4, NRY) | <0.001 |
High-risk (n = 290) | 36.7 (28.4–47.7) | 99.8 (80.1, NRY) | ||
Tandem ASCT and maintenance given | ||||
Standard-risk (n = 29) | 47.4 (21.9–73.5) | 0.4 | NRY (NRY-NRY) | 0.1 |
High-risk (n = 153) | 35.3 (26.2–47.8) | 84.1 (69.7-133.0) | ||
No. of ASCTs—High-risk* | ||||
Single (n = 503) | 25.1 (23.1–30.5) | 0.01 | 91.5 (75.8-106) | 0.008 |
Tandem (n = 201) | 35.4 (26.2–52.4) | 84.4 (70.3-NRY) | ||
No. of ASCTs—Standard-risk | ||||
Single (n = 1178) | 46.5 (43.1-51.3) | <0.001 | 158.6 (147.1-NRY) | / |
Tandem (n = 37) | 33.8 (29.4-NRY) | NRY (NRY–NRY) | ||
No. of ASCTs—Unknown-risk | ||||
Single (n = 1825) | 32.7 (31.2–35.4) | 0.23 | 120.6 (110.6-134) | 0.02 |
Tandem (n = 76) | 34.2 (22.9–42.8) | 113.3 (73.6-NRY) | ||
Consolidation given | ||||
No (n = 3616) | 34.4 (32.9–36.6) | <0.001 | 124 (118-135) | 0.07 |
Yes (n = 205) | 55.3 (43.9–76.0) | NRY (114-NRY) | ||
No Consolidation given | ||||
Standard-risk (n = 1117) | 45.9 (41–50.8) | 164.4 (147.1-NRY) | ||
High-risk (n = 630) | 26.6 (23.6–32) | <0.001 | 87.9 (76.4-103) | <0.001 |
Unknown risk (n = 1868) | 32.3 (30.8–34.6) | 119.5 (110.4-128) | ||
Consolidation given | ||||
Standard-risk (n = 98) | 52.2 (43.9–78.3) | NRY (114-NRY) | ||
High-risk (n = 74) | 42.4 (26.7-NRY) | <0.001 | NRY (68.5-NRY) | <0.001 |
Unknown risk (n = 33) | 86.9 (54.8-NRY) | NRY (NRY-NRY) | ||
Maintenance given (any) | ||||
Yes (n = 2061) | 48.8 (46.1–53.5) | <0.001 | 159 (142-NRY) | <0.001 |
No (n = 1760) | 24.5 (23.2–26.7) | 105 (97.2-115) | ||
No Maintenance given | ||||
Standard-risk (n = 417) | 28.9 (23.7–33.7) | 129.8 (107.9-NRY) | ||
High-risk (n = 261) | 13.4 (11.9–18.8) | <0.001 | 63.5 (52.3-82.9) | <0.001 |
Unknown risk (n = 1082) | 25.7 (24–28.1) | 105.1 (97.2-116.5) | ||
Maintenance given (any) | ||||
Standard-risk (n = 798) | 54.7 (47.9–60.3) | 164.4 (158.6-NRY) | ||
High-risk (n = 443) | 36.6 (32.2–47.5) | <0.001 | 97.4 (87.9-NRY) | <0.001 |
Unknown risk (n = 820) | 48.7 (44.2–58.7) | 158.5 (136.6-NRY) | ||
No. of induction regimens and no maintenance | ||||
1 regimen (n = 1602) | 32.0 (30.0–34.1) | 0.021 | 108 (100.1-117) | <0.001 |
2 regimens (n = 158) | 23.5 (20.1–33.4) | 75.8 (39.6-118) | ||
1 induction and no maintenance | ||||
Standard-risk (n = 377) | 30.4 (25.3–35.4) | 0.005 | 129.0 (107.5-164.2) | 0.1 |
High-risk (n = 224) | 16.1 (12.2–20.4) | 68.0 (51.8-91.9) | ||
2 inductions and no maintenance | ||||
Standard-risk (n = 40) | 13.5 (4.0–24.4) | 0.3 | 75.6 (27.0-NRY) | 0.5 |
High-risk (n = 37) | 11.4 (5.4–16.4) | 41.3 (23.1-91.0) | ||
No. of induction regimens & maintenance | ||||
1 regimen (n = 1843) | 55.3 (52.1–60.5) | 158.6 (142.5-NRY) | ||
2 regimens (n = 218) | 51.1 (44.7 70.7) | 0.11 | NRY (135.1 NRY) | 0.13 |
1 induction and maintenance | ||||
Standard-risk (n = 726) | 55.1 (48.4–61.5) | 0.002 | 164.0 (158.4-NRY) | <0.001 |
High-risk (n = 391) | 35.6 (30.9–47.3) | 97.0 (81.2-NRY) | ||
2 inductions and maintenance | ||||
Standard-risk (n = 72) | 47.1 (27.3–57.1) | 0.1 | NRY (85.3-NRY) | 0.001 |
High-risk (n = 52) | 36.5 (22.6–60.9) | 84.1 (59.9-NRY) | ||
