Fig. 6: ‘Two-hop’ neighborhood of the eight genes identified as being predictive of PFS.

Each line or edge represents the interaction between a gene-pair in a network, comparing the median interactions observed in the high-risk group compared with those in the low-risk group. Blue edges indicate that the connections are more robust in the high-risk group, while orange edges are more fragile, risk being defined by the RNA-Seq-based clustering analysis. A: BUB1, B: MCM6, C: NOSTRIN, D: PAM, E: RNF115, F: SNCAIP, G: SPRR2A, H: WEE1. Higher resolution images are available at www.github.com/aksimhal/mm-orc-subtypes.