Table 1 Differential gene expression analysis according to ORC-based risk groups.

From: Gene interaction network analysis in multiple myeloma detects complex immune dysregulation associated with shorter survival

Pathway

Genes

Q-value

Directionality

Mitotic spindle

BIN1, GEMIN4, LATS1

5.15e-3

Underexpressed

DNA repair

ADA, CCNO, ERCC4, GTF2H5, NFX1, DCTN4

9.16e-5

Overexpressed

IL6 JAK STAT3 signaling

CCL7, JUN, IFNGR1, IL2RA

1.52e-3

Overexpressed

Inflammatory response

CCL7, KIF1B, MEP1A, PDPN, KCNJ2

1.62e-3

Overexpressed

P53 pathway

ADA, JUN, SAT1, PLK2, NOL8

1.62e-3

Overexpressed

Apoptosis

JUN, IFNGR1, SAT1, PAK1

6.44e-3

Overexpressed

  1. Directionality indicates the gene-set expression in the high-risk group compared with the low-risk group, with risk being defined by ORC of RNA-Seq data.
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