Table 1 Baseline characteristics (1st NLR).
No MPN | Transition to MPNa | Prevalent MPN | p value | ||||
---|---|---|---|---|---|---|---|
N | % / Mean (SD) | N | % / Mean (SD) | N | % / Mean (SD) | ||
Sex | |||||||
Female | 471,929 | 56.7 | 1042 | 58.1 | 354 | 57.5 | 0.4 |
Male | 361,091 | 43.3 | 752 | 41.9 | 262 | 42.5 | |
Age | 833,020 | 51.4 (18.8) | 1794 | 61.4 (14.4) | 616 | 68.3 (13.8) | <2.2 × 10–16 |
Education | |||||||
Primary school | 201,035 | 24.1 | 524 | 29.2 | 186 | 30.2 | <2.2 × 10–16 |
High school | 39,975 | 4.8 | 47 | 2.6 | 11 | 1.8 | |
Vocational training | 294,608 | 35.4 | 710 | 39.6 | 225 | 36.5 | |
Bachelor | 135,398 | 16.3 | 285 | 15.9 | 65 | 10.6 | |
Higher education | 102,396 | 12.3 | 132 | 7.4 | 51 | 8.3 | |
Unknown | 59,608 | 7.2 | 96 | 5.4 | 78 | 12.7 | |
Glucocorticoids | |||||||
No use | 820,581 | 98.5 | 1769 | 98.6 | 601 | 97.6 | 0.3 |
Early use | 8474 | 1 | 15 | 0.8 | 10 | 1.6 | |
Late use | 3965 | 0.5 | 10 | 0.6 | 5 | 0.8 | |
Comorbidities | |||||||
Hypertension | 207,457 | 24.9 | 713 | 39.7 | 349 | 56.7 | <2.2 × 10–16 |
Hyperlipidemia | 71,689 | 8.6 | 250 | 13.9 | 95 | 15.4 | <2.2 × 10–16 |
IHD | 60,607 | 7.3 | 198 | 11 | 118 | 19.2 | <2.2 × 10–16 |
COPD | 29,574 | 3.6 | 82 | 4.6 | 56 | 9.1 | 7.4 × 10–14 |
Arterial disease | 74,689 | 9 | 273 | 15.2 | 187 | 30.4 | <2.2 × 10–16 |
Venous disease | 19,541 | 2.3 | 69 | 3.8 | 53 | 8.6 | <2.2 × 10–16 |
CCI-score | |||||||
0 | 591,720 | 71 | 1097 | 61.1 | 246 | 39.9 | <2.2 × 10–16 |
1–2 | 185,573 | 22.3 | 560 | 31.2 | 237 | 38.5 | |
≥3 | 55,727 | 6.7 | 137 | 7.6 | 133 | 21.6 | |
Blood cell counts | |||||||
Neutrophils (x109/L) | 833,020 | 5.1 (3) | 1794 | 6.8 (4.4) | 616 | 7 (5.9) | <2.2 × 10–16 |
Lymphocytes (x109/L) | 833,020 | 2.1 (2) | 1794 | 2.1 (1.4) | 616 | 1.7 (0.9) | <2.2 × 10–16 |
NLR | 833,020 | 3.1 (3.4) | 1794 | 3.9 (3.5) | 616 | 5 (5.4) | <2.2 × 10–16 |
CRP-level | |||||||
No CRP | 442,750 | 53.2 | 1121 | 62.5 | 506 | 82.1 | <2.2 × 10–16 |
CRP ≤ 10 mg/L | 293,243 | 35.2 | 517 | 28.8 | 71 | 11.5 | |
CRP > 10 mg/L | 97,027 | 11.6 | 156 | 8.7 | 39 | 6.3 |