Fig. 1: Landscape of effector cellular therapy for DLBCL therapy.
From: Bispecific antibodies and CAR-T cells: dueling immunotherapies for large B-cell lymphomas
Bispecific T cell engagers (left) include BiTEs like blinatumomab, fused full-length antibodies like the DLBCL-approved products epcoritamab and glofitamab, and multivalent constucts like imovtamab. Approved CAR-19 therapies (top right) are manufactured ex vivo from each patient’s T cells, requiring 20–40 days. Viral or nanoparticle delivery of CAR genes (bottom right) in vivo is one of many investigational ways to potentially accelerate targeted cell therapy delivery.
