Fig. 3: Benign T-cell precursors show polytypic T-cell receptor constant β chain (TRBC) expression using dual cytoplasmic TRBC1 and TRBC2 staining. | Blood Cancer Journal

Fig. 3: Benign T-cell precursors show polytypic T-cell receptor constant β chain (TRBC) expression using dual cytoplasmic TRBC1 and TRBC2 staining.

From: Dual T-cell constant β chain (TRBC)1 and TRBC2 staining for the identification of T-cell neoplasms by flow cytometry

Fig. 3

A Representative immunophenotypic findings of a mediastinal mass involved by thymoma, showing benign CD4/CD8-double-positive T-cell precursors (violet) gradually acquiring surface CD3 expression as they mature into single-positive T-cells (blue). B Left: Double-positive T-cell precursors (violet) gradually acquire surface TRBC1 and TRBC2 expression while maturing into polytypic single-positive cells (blue). Right: Cytoplasmic TRBC1 and TRBC2 staining demonstrates polytypic TRBC expression on double-positive T-cell precursors. C Dual cytoplasmic TRBC1 and TRBC2 staining showing polytypic TRBC expression on double-positive and single-positive T-cell precursors. D TRBC2:TRBC1 ratios on double-positive and single-positive immature T-cells, using cytoplasmic dual staining on ten tissue biopsies with benign T-cell precursors.

Back to article page