Table 4 Selected publications on patients with multiple myeloma with long-term remission.

From: Multiple myeloma patients with a long remission after autologous hematopoietic stem cell transplantation

Study

Center

Population studied

LTR n (%); definition

LTR characteristic (compared to non-LTR)

Induction (in LTR)

Post-autoHCT Maintenance (in LTR)

Median PFS (in LTR)

Pasvolsky et al. (2024)

MD Anderson Cancer Center, Houston, TX, USA

1576 patients with NDMM that received upfront autoHCT, between 2000-2014

244 (15%), PFS ≥ 8 years following autoHCT

Younger age, less HRCA (4%), lower R-ISS, lower BM plasma cell infiltration

Imid + dexa (29%), VRD (18%), BOR+dexa (13%)

63%

169.3 months (95% CI 153.1-NR)

Oliver-Caldes et al. (2022)

Hospital Clinic de Barcelona, Spain

250 patients with NDMM that received upfront autoHCT, between 1990-2015

54 (21.6%); sustained response for ≥5 years following autoHCT

Younger age, female gender, better ECOG, lower ISS stage, lower BM plasma cell infiltration, lower serum calcium CRP and LDH [9% HRCA]

LEN-based (21%), BOR-based (55%)

57.4%

191 months for non-relapsers, 24 months for relapsersa

Paquin et al. (2020)

Mayo Clinic, Rochester, MN, USA

509 patients with NDMM that received autoHCT within 12 months, between 1998-2006

46 (9%); PFS > 8 years following autoHCT without maintenance

Median age 57 years, 61% female, 54% ISS stage Ib [2.5% HRCA]

Td (35%), chemotherapy (33%), high-dose dexa (22%)

0%

13.8 years (95% CI 10.5-18.5)

Terpos et al. (2020)

Alexandra General Hospital, Greece

406 patients with NDMM, between 1994-2010c

36 (8.8%); PFS ≥ 7 years

Younger age, better ECOG, higher Hb, better CrCl, lower ISS, less HRCA (0%), more normal pattern of marrow infiltration (on MRI)

Chemotherapy/Bor-based/Thal-based/LEN-basedd

50%

10 years

  1. aLandmark analysis starting at 5-years post-autoHCT; relapsers/non-relapsers within LTR group.
  2. bNot compared to non-LTR.
  3. c61% of LTR and 23% of non-LTR received upfront autoHCT.
  4. dPercentages not provided.
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