Fig. 1: Accentuated thymic aging in cALL survivors is modulated by sex. | Blood Cancer Journal

Fig. 1: Accentuated thymic aging in cALL survivors is modulated by sex.

From: Premature thymic functional senescence is a hallmark of childhood acute lymphoblastic leukemia survivorship

Fig. 1

A Correlation between chronological age and TREC levels. p values compare regression lines (slope and intercept). Pearson correlations: cALL males (n = 124, r = −0.356, R2 = 0.127; p < 0.0001) ; cALL females (n = 124; r = −0.501; R2 = 0.251; p < 0.0001); control males (n = 150; r = −0.466; R2 = 0.217; p < 0.0001); control females (n = 131, r = −0.504, R2 = 0.254; p < 0.0001). B Each line represents the chronoage and immunoage (in years) of one survivor; n = 124 males and 124 females. p values calculated using Wilcoxon test. C Comparison of immunoage gain in male and female cALL survivors. p values calculated using Mann–Whitney test; n = 124 females; n = 124 males. Correlation between TREC (D) or immnuoage gain (F) and age at diagnosis. Correlation between TREC (E) or immnuoage gain (G) and time elapse since diagnosis.

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