Fig. 3: Accentuated thymic functional senescence is associated with metabolic syndrome.

Association between thymic aging marker as measured by TREC levels (A) or years of immunoage gain (B) and metabolic syndrome status. C ROC curve of thymic aging marker as measured by TREC levels (C) and immunoage gain (D) as a metabolic syndrome incidence measure in cALL survivors (n = 22 MS; n = 220 no-MS). MS metabolic syndrome. The p value was calculated using the Mann–Whitney test.